Therapeutic Application, Phytoactives and Pharmacology of Tinospora cordifolia: An Evocative Review / 中国结合医学杂志

Tinospora cordifolia (Guduchi or Gurjo), a herbaceous vine or climbing deciduous shrub, is consider as an important medicine in the Ayurvedic system of medication, which is available in India, China, Myanmar, Bangladesh and Srilanka. Menispermaceae is the family of this compound. T. cordifolia have a variety of properties to treat various ailments such as fevers, jaundice, diabetes, dysentery, urinary infections, and skin diseases. This compound has been subjected to many chemicals, pharmacological, pre-clinical, or clinical investigations and some new therapeutic potential effects have been indicated. This review aims to summarize the critical information concerning in areas of chemical constituents, chemical structure, and pharmacokinetic activities such as anti-diabetic, anticancer, immune-modulatory, antivirus (especially in silico study about COVID-19), antioxidant, antimicrobial, hepatoprotective and its effect on cardiovascular and neurological disorders as well as rheumatoid arthritis. This traditional herb needs more experimental study on the clinical, pre-clinical study, and clinical efficacy of these compounds for the prevention and treatment of COVID-19 and needs large-scale clinical studies to prove the clinical efficacy of this compound, especially in stress-related diseases and other neuronal disorders.

Protective effects of Butea frondosa leaves against stress induced immune impairment in sprague dawley rats

Stress is thought to impair immune function through emotional or behavioral manifestations thus the present study was done to assessed the effect of ethanolic extract of Butea frondosa [BF] leaves on behaviour, immunomodulatory activity and brain acetyl cholinesterase activity in normal and stress induced male rats. Neuroprotective effects of BF, doses [100,200,400mg/kg p.o] were measured by assessing the changes in the behaviour and the immunity of the rats. In stress control, the results indicated that the retention transfer latency, time spent in a closed arm, agglutination , total leukocytes counts [TLC], total paw edema ,size of spleen , decreased significantly [p<0.01] while glucose level, size of the kidney and the liver, AChE activity increased significantly [p<0.01] in comparison with normal control. In BF [200mg/kg] treated rats, the results indicated that the time spent in a closed arm [p<0.01], agglutination [p<0.01], TLC [p<0.01], total paw edema [p<0.05], size of spleen[p<0.01] , increased significantly while glucose level [p<0.01], size of the kidney and the liver [p<0.01], AChE activity [p<0.01] decreased significantly in comparison with stress control. This study therefore concluded that the ethanolic extract of BF [200mg/kg] showed a protective effect against the stress induced impaired immune system and the psychological disorders